In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies

2004349 citationsJournal Articlebronze Open Access

Authors

Ilma R. Korponay‐Szabó · Tampere University

T Halttunen · Tampere University Hospital

Z Szalai · Heim Pál Gyermekkórház

K Laurila · Tampere University Hospital

R Király · University of Debrecen

J B Kovács · Heim Pál Gyermekkórház

L Fésüs · University of Debrecen

M Mäki

Abstract

Coeliac IgA targets jejunal TG2 early in disease development even when endomysial antibodies are not present in the circulation. Extraintestinal target sites of coeliac IgA further indicate that humoral immunity may have a pathogenetic role.

Topics & Keywords

Celiac Disease Research and Management Intestinal and Peritoneal Adhesions Eosinophilic Esophagitis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 53, Issue 5, pp. 641-648

DOI: 10.1136/gut.2003.024836

Field-Weighted Citation Impact: 8.32