Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Reveals Early and Delayed Afterdepolarizations

2012134 citationsJournal Articlegold Open Access

Authors

Kirsi Kujala · Tampere University of Applied Sciences

Jere Paavola · Tampere University

Anna Lahti · Tampere University of Applied Sciences

Kim Larsson · Tampere University of Applied Sciences

Mari Pekkanen-Mattila · Tampere University

Matti Viitasalo · Helsinki University Hospital

Annukka M. Lahtinen

Abstract

This cell model shows aberrant Ca(2+) cycling characteristic of CPVT and in addition to DADs it displays EADs. This cell model for CPVT provides a platform to study basic pathology, to screen drugs, and to optimize drug therapy.

Topics & Keywords

Cardiac electrophysiology and arrhythmias Ion channel regulation and function Neuroscience and Neural Engineering

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 7, Issue 9, pp. e44660-e44660

DOI: 10.1371/journal.pone.0044660

Field-Weighted Citation Impact: 8.63