Trans-generational epigenetic regulation of C. elegans primordial germ cells

2010111 citationsJournal Articlegold Open Access

Authors

Hirofumi Furuhashi · Tohoku University

Teruaki Takasaki · University of California, Santa Cruz

Andreas Rechtsteiner · University of California, Santa Cruz

Tengguo Li · Emory University

Hiroshi Kimura · Osaka University

Paula M Checchi · Emory University

Susan Strome ·

Abstract

Our data suggest a model in which MES-4 helps to maintain an 'epigenetic memory' of transcription that occurred in germ cells of previous generations, and that MES-4 and its epigenetic product are essential for normal germ cell development.

Topics & Keywords

Genetics, Aging, and Longevity in Model Organisms Epigenetics and DNA Methylation CRISPR and Genetic Engineering

Publication Details

Published in: Epigenetics & Chromatin

Volume 3, Issue 1, pp. 15-15

DOI: 10.1186/1756-8935-3-15

Field-Weighted Citation Impact: 2.59

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Trans-generational epigenetic regulation of C. elegans primordial germ cells

Authors

Abstract

Topics & Keywords

Publication Details