Self Modeling Curve Resolution

This paper presents a method for determining the shapes of two overlapping functions f 1(x) and f 2(x) from an observed set of additive mixtures, [α i f 1(x) + β i f 2(x); i = 1, …, n), of the two functions. This type of problem arises in the fields of spectrophotometry, chromatography, kinetic model building, and many others. The methods described by this paper are based on the use of principal component techniques, and produce two bands of functions, each of which contains one of the unknown, underlying functions. Under certain mild restrictions on the fj (x), each band reduces to a single curve, and the fi (x) are completely determined by the analysis.