Alterations in Intracellular Calcium Handling Associated With the Inverse Force-Frequency Relation in Human Dilated Cardiomyopathy

1995379 citationsJournal Article

Authors

Burkert Pieske · Heart and Diabetes Center North Rhine-Westphalia

Bodo Kretschmann · Heart and Diabetes Center North Rhine-Westphalia

Markus Meyer · Heart and Diabetes Center North Rhine-Westphalia

Christian Holubarsch · Heart and Diabetes Center North Rhine-Westphalia

Jörg Weirich · Heart and Diabetes Center North Rhine-Westphalia

Herbert Posival · Heart and Diabetes Center North Rhine-Westphalia

Abstract

These data indicate that the altered force-frequency relation of the failing human myocardium results from disturbed excitation-contraction coupling with decreased calcium cycling at higher rates of stimulation.

Topics & Keywords

Neuroscience and Neural Engineering Ion channel regulation and function Cardiac electrophysiology and arrhythmias

Publication Details

Published in: Circulation

Volume 92, Issue 5, pp. 1169-1178

DOI: 10.1161/01.cir.92.5.1169

Field-Weighted Citation Impact: 7.78

Command Palette

Alterations in Intracellular Calcium Handling Associated With the Inverse Force-Frequency Relation in Human Dilated Cardiomyopathy

Authors

Abstract

Topics & Keywords

Publication Details