Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells

2011195 citationsJournal Articlegold Open Access

Authors

Arpita Konar · Banaras Hindu University

Navjot Shah · National Institute of Advanced Industrial Science and Technology

Rumani Singh · National Institute of Advanced Industrial Science and Technology

Nishant Saxena · National Institute of Advanced Industrial Science and Technology

Sunil C. Kaul · National Institute of Advanced Industrial Science and Technology

Renu Wadhwa · National Institute of Advanced Industrial Science and Technology

Abstract

Our study suggested that besides cholinergic blockade, scopolamine-induced memory loss may be associated with oxidative stress and Ashwagandha i-Extract, and withanone may serve as potential preventive and therapeutic agents for neurodegenerative disorders and hence warrant further molecular analyses.

Topics & Keywords

Medicinal Plants and Neuroprotection Phytochemicals and Medicinal Plants Cholinesterase and Neurodegenerative Diseases

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: PLoS ONE

Volume 6, Issue 11, pp. e27265-e27265

DOI: 10.1371/journal.pone.0027265

Field-Weighted Citation Impact: 25.27