Dynamic Changes in Regulatory T Cells Are Linked to Levels of Diet-Induced Hypercholesterolemia

2011183 citationsJournal Article

Authors

Elena Maganto-García · Brigham and Women's Hospital

Margarite L. Tarrio · Brigham and Women's Hospital

Nir Grabie · Brigham and Women's Hospital

De-xiu Bu · Brigham and Women's Hospital

Andrew H. Lichtman · Brigham and Women's Hospital

Abstract

Prolonged hypercholesterolemia impairs Treg but not effector T cell accumulation in lesions, but reversal of hypercholesterolemia can prevent loss of lesional Treg. Therefore, cholesterol-lowering therapies may induce dynamic and beneficial changes in Treg:effector T cell ratios in atherosclerotic lesions.

Topics & Keywords

Atherosclerosis and Cardiovascular Diseases T-cell and B-cell Immunology Immune Cell Function and Interaction

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 124, Issue 2, pp. 185-195

DOI: 10.1161/circulationaha.110.006411

Field-Weighted Citation Impact: 4.94