Pharmacokinetics and Antitumor Efficacy of Paclitaxel–Cyclodextrin Complexes Loaded in Mucus-Penetrating Nanoparticles for Oral Administration

201424 citationsJournal Article

Authors

Leticia Corrales · Universidad de Navarra

Abstract

PTX orally administered in poly(anhydride) NPs, combined with cyclodextrins and poly(ethylene glycol), displayed sustained plasma levels and significant antitumor effect in a syngenic tumor model of carcinoma in mice.

Topics & Keywords

Advanced Drug Delivery Systems Drug Solubulity and Delivery Systems Nanoparticle-Based Drug Delivery

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Nanomedicine

Volume 9, Issue 14, pp. 2109-2121

DOI: 10.2217/nnm.13.199

Field-Weighted Citation Impact: 1.42