A Randomized Trial of Tenecteplase versus Alteplase for Acute Ischemic Stroke

2012666 citationsJournal Article

Authors

Mark Parsons · John Hunter Hospital

Neil J. Spratt · Hunter Medical Research Institute

Andrew Bivard · Hunter Medical Research Institute

Bruce Campbell · The Royal Melbourne Hospital

Kong Mun Chung · Hunter Medical Research Institute

Ferdinand Miteff · Hunter Medical Research Institute

Bill O’Brien

Abstract

Tenecteplase was associated with significantly better reperfusion and clinical outcomes than alteplase in patients with stroke who were selected on the basis of CT perfusion imaging. (Funded by the Australian National Health and Medical Research Council; Australia New Zealand Clinical Trials Registry number, ACTRN12608000466347.).

Topics & Keywords

Acute Ischemic Stroke Management S100 Proteins and Annexins Protease and Inhibitor Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 366, Issue 12, pp. 1099-1107

DOI: 10.1056/nejmoa1109842

Field-Weighted Citation Impact: 40.31