Osteoarthritis: New Insights

Letters1 January 2002Osteoarthritis: New InsightsDavid T. Felson, MD, MPH and Timothy McAlindon, MD, MPHDavid T. Felson, MD, MPHBoston University School of Medicine, Boston, MA 02118 and Timothy McAlindon, MD, MPHBoston University School of Medicine, Boston, MA 02118Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-1-200201010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:As coauthors of the review of therapy in osteoarthritis who are not funded by companies producing COX-2 inhibitors or any brands of glucosamine or chondroitin, we can comment impartially on Dr. Lindow's concerns about any bias in advocating COX-2 inhibitors compared with glucosamine or chondroitin. We consider glucosamine and chondroitin promising agents for osteoarthritis. Our meta-analysis of trials of these agents suggested several biases, including probable publication bias, that should inject caution into interpretation of the positive trial results. We should note that since the publication of our meta-analysis, several new randomized, placebo-controlled trials have been published that ...References1. Rindone JP, Hiller D, Collacott E, Nordhaugen N, Arriola G. Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee. West J Med. 2000;172:91-4. [PMID: 10693368] CrossrefMedlineGoogle Scholar2. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol. 1999;26:2423-30. [PMID: 10555905] MedlineGoogle Scholar3. Leffler CT, Philippi AF, Leffler SG, Mosure JC, Kim PD. Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study. Mil Med. 1999;164:85-91. [PMID: 10050562] CrossrefMedlineGoogle Scholar4. Altman RD, Moskowitz R. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group. J Rheumatol. 1998;25:2203-12. [PMID: 9818665] MedlineGoogle Scholar5. Lohmander LS, Dalén N, Englund G, Hämäläinen M, Jensen EM, Karlsson K, et al . Intra-articular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomised, double blind, placebo controlled multicentre trial. Hyaluronan Multicentre Trial Group. Ann Rheum Dis. 1996;55:424-31. [PMID: 8774159] CrossrefMedlineGoogle Scholar6. Trock DH, Bollet AJ, Dyer RH, Fielding LP, Miner WK, Markoll R. A double-blind trial of the clinical effects of pulsed electromagnetic fields in osteoarthritis. J Rheumatol. 1993;20:456-60. [PMID: 8478852] MedlineGoogle Scholar7. Trock DH, Bollet AJ, Markoll R. The effect of pulsed electromagnetic fields in the treatment of osteoarthritis of the knee and cervical spine. Report of randomized, double blind, placebo controlled trials. J Rheumatol. 1994;21:1903-11. [PMID: 7837158] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Boston University School of Medicine, Boston, MA 02118 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOsteoarthritis: New Insights. Part 2: Treatment Approaches Conference Chair: David T. Felson , Conference Organizer: Reva C. Lawrence , Discussants: Marc C. Hochberg , Timothy McAlindon , Paul A. Dieppe , Marian A. Minor , Steven N. Blair , Brian M. Berman , James F. Fries , Morris Weinberger , Kate R. Lorig , Joshua J. Jacobs , and Victor Goldberg Osteoarthritis: New Insights Thomas E. Lindow Osteoarthritis: New Insights David D. Waddell Osteoarthritis: New Insights Paul J. Rosch Osteoarthritis: New Insights Robert H. Palmer Metrics Cited byAn Emerging Target in the Battle against Osteoarthritis: Macrophage PolarizationA study assessing intra-articular PRP vs PRP with HMW HA vs PRP with LMW HA in early knee osteoarthritis 1 January 2002Volume 136, Issue 1Page: 88KeywordsChondroitinClinical trialsCyclooxygenase 2Food and Drug AdministrationHeart rateIntent to treat analysisKneesOsteoarthritisRandomized trialsRheumatology ePublished: 1 January 2002 Issue Published: 1 January 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...