Synergistic Effect of β-Amyloid and Neurodegeneration on Cognitive Decline in Clinically Normal Individuals

2014323 citationsJournal Article

Authors

Elizabeth C. Mormino · Massachusetts General Hospital

Rebecca A. Betensky · Harvard University

Trey Hedden · Massachusetts General Hospital

Aaron P. Schultz · Massachusetts General Hospital

Rebecca E. Amariglio · Brigham and Women's Hospital

Dorene M. Rentz · Harvard University

Keith A. Johnson

Abstract

The co-occurrence of Aβ and ND accelerates cognitive decline in CN individuals. Therefore, both factors are important to consider in upcoming secondary prevention trials targeting CN individuals at high risk for progression to the symptomatic stages of Alzheimer disease.

Topics & Keywords

Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Functional Brain Connectivity Studies

Publication Details

Published in: JAMA Neurology

Volume 71, Issue 11, pp. 1379-1379

DOI: 10.1001/jamaneurol.2014.2031

Field-Weighted Citation Impact: 21.46

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Synergistic Effect of β-Amyloid and Neurodegeneration on Cognitive Decline in Clinically Normal Individuals

Authors

Abstract

Topics & Keywords

Publication Details