Arachidonic acid induction of Rho-mediated transendothelial migration in prostate cancer

201444 citationsJournal Articlehybrid Open Access

Authors

M.D. Brown · Cancer Research UK Manchester Institute

Claire A. Hart · University of Manchester

Thomas Tawadros · Manchester Academic Health Science Centre

Noel W. Clarke · Manchester Academic Health Science Centre

Abstract

AA-induced TEM is mediated by the induction of a Rho-driven amoeboid phenotype. Inhibition of this cell migratory process may be an important therapeutic target in high-risk CaP.

Topics & Keywords

Cancer, Lipids, and Metabolism Prostate Cancer Treatment and Research Inflammatory mediators and NSAID effects

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Cancer

Volume 110, Issue 8, pp. 2099-2108

DOI: 10.1038/bjc.2014.99

Field-Weighted Citation Impact: 1.55