The impact of primary prophylaxis with granulocyte colony-stimulating factors on febrile neutropenia during chemotherapy: a systematic review and meta-analysis of randomized controlled trials

2015127 citationsReviewhybrid Open Access

Authors

Abstract

In this meta-analysis, using MTC without adjustment for RDI, PP with all G-CSFs evaluated reduced the FN risk in patients receiving myelosuppressive chemotherapy. Future studies are needed to assess the influence of RDI on FN outcomes and to eliminate potential bias between G-CSF arms receiving more intensive chemotherapy than control arms.

Topics & Keywords

Neutropenia and Cancer Infections Blood disorders and treatments Cancer therapeutics and mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Supportive Care in Cancer

Volume 23, Issue 11, pp. 3131-3140

DOI: 10.1007/s00520-015-2686-9

Field-Weighted Citation Impact: 4.60