Transcriptional Activation of Steroidogenic Factor-1 by Hypomethylation of the 5′ CpG Island in Endometriosis

2007216 citationsJournal Article

Authors

Qing Xue · Peking University

Zhihong Lin · Northwestern University

Ping Yin · Northwestern University

Magdy P. Milad · Northwestern University

You-Hong Cheng · Northwestern University

Edmond Confino · Northwestern University

Scott Reierstad ·

Abstract

This is the first demonstration of methylation-dependent regulation of SF-1 in any mammalian tissue. These findings point to a new mechanism for targeting local estrogen biosynthesis in endometriosis.

Topics & Keywords

Endometriosis Research and Treatment Reproductive System and Pregnancy Estrogen and related hormone effects

UN Sustainable Development Goals

Life below water

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 92, Issue 8, pp. 3261-3267

DOI: 10.1210/jc.2007-0494

Field-Weighted Citation Impact: 11.62