Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Diagnostics

2007219 citationsJournal Articlebronze Open Access

Authors

Kristina Lagerstedt‐Robinson · Ludwig Cancer Research

Thalia D. Liu · University of Helsinki

Jana Vandrovcová · Karolinska Institutet

B. Halvarsson · Karolinska University Hospital

Mark Clendenning · University of California, San Diego

Thierry Frébourg · University of Helsinki

Nikolaos G. Papadopoulos

Abstract

Our findings suggest that missense MMR gene mutations are common in HNPCC and that germline MMR mutations are also found in patients with MSI-negative tumors.

Topics & Keywords

Genetic factors in colorectal cancer Colorectal Cancer Screening and Detection Multiple and Secondary Primary Cancers

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 99, Issue 4, pp. 291-299

DOI: 10.1093/jnci/djk051

Field-Weighted Citation Impact: 15.47