A Trial of Combination Antimalarial Therapies in Children from Papua New Guinea

2008203 citationsJournal Articlebronze Open Access

Authors

Harin Karunajeewa · University of Western Australia

Ivo Müeller · Papua New Guinea Institute of Medical Research

Michèle Senn · Papua New Guinea Institute of Medical Research

Enmoore Lin · Papua New Guinea Institute of Medical Research

Irwin Law · University of Western Australia

P. Servina Gomorrai · Papua New Guinea Institute of Medical Research

Olive Oa

Abstract

The most effective regimens were artemether-lumefantrine against P. falciparum and dihydroartemisinin-piperaquine against P. vivax. The relatively high rate of treatment failure with dihydroartemisinin-piperaquine against P. falciparum may reflect cross-resistance between chloroquine and piperaquine. (Australian New Zealand Clinical Trials Registry number, ACTRN12605000550606.)

Topics & Keywords

Malaria Research and Control Mosquito-borne diseases and control Drug-Induced Hepatotoxicity and Protection

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: New England Journal of Medicine

Volume 359, Issue 24, pp. 2545-2557

DOI: 10.1056/nejmoa0804915

Field-Weighted Citation Impact: 25.66