GEP100/Arf6 Is Required for Epidermal Growth Factor-Induced ERK/Rac1 Signaling and Cell Migration in Human Hepatoma HepG2 Cells

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Authors

Zhenzhen Hu · Second Affiliated Hospital of Nanjing Medical University

Jun Du · Nanjing Medical University

Ling Yang

Yichao Zhu · Nanjing Medical University

Yang Yu · Nanjing Medical University

Datong Zheng · Second Affiliated Hospital of Nanjing Medical University

Akimasa Someya · Juntendo University

Abstract

Taken together, this study highlights the function of the PH domain of GEP100 and its regulated Arf6/ERK/Rac1 signaling cascade in EGF-induced hepatoma cell migration. These findings could provide a rationale for designing new therapy based on inhibition of hepatoma metastasis.

Topics & Keywords

Protein Kinase Regulation and GTPase Signaling Cancer Mechanisms and Therapy Ubiquitin and proteasome pathways

Publication Details

Published in: PLoS ONE

Volume 7, Issue 6, pp. e38777-e38777

DOI: 10.1371/journal.pone.0038777

Field-Weighted Citation Impact: 1.88

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GEP100/Arf6 Is Required for Epidermal Growth Factor-Induced ERK/Rac1 Signaling and Cell Migration in Human Hepatoma HepG2 Cells

Authors

Abstract

Topics & Keywords

Publication Details