Acute Disseminated Encephalomyelitis in Children: Discordant Neurologic and Neuroimaging Abnormalities and Response to Plasmapheresis

2005130 citationsJournal Article

Authors

Divya S. Khurana · Pediatrics and Genetics

Joseph J. Melvin · Pediatrics and Genetics

Sanjeev V. Kothare · Pediatrics and Genetics

Ignacio Valencia · Pediatrics and Genetics

H. Huntley Hardison · Pediatrics and Genetics

Sabrina W. Yum · Pediatrics and Genetics

Eric N. Faerber

Abstract

Presentation of ADEM with delayed development of MRI lesions in deep gray matter and brainstem may herald a prolonged clinical course and lack of response to glucocorticoid therapy. Plasmapheresis might be an effective therapeutic intervention in these patients. The role of plasmapheresis versus corticosteroids and intravenous immunoglobulin as a primary treatment of ADEM needs to be investigated further.

Topics & Keywords

Multiple Sclerosis Research Studies Autoimmune and Inflammatory Disorders Research Peripheral Neuropathies and Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PEDIATRICS

Volume 116, Issue 2, pp. 431-436

DOI: 10.1542/peds.2004-2038

Field-Weighted Citation Impact: 3.12