Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993710 citationsJournal Article

Authors

Matthew D. Linnik · Institut Mérieux (France)

R. Howard Zobrist · Institut Mérieux (France)

Marsa D. Hatfield · Institut Mérieux (France)

Abstract

New protein synthesis appears to contribute to ischemic cell death in which endonucleolytic DNA degradation is apparent. These observations implicate programmed cell death in ischemic injury and may open unique therapeutic approaches for the preservation of neurons in stroke.

Topics & Keywords

Mitochondrial Function and Pathology Neuroscience and Neuropharmacology Research Anesthesia and Neurotoxicity Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stroke

Volume 24, Issue 12, pp. 2002-2008

DOI: 10.1161/01.str.24.12.2002

Field-Weighted Citation Impact: 15.45