Imaging Dopamine Receptors in the Human Brain by Positron Tomography

1983742 citationsJournal Article

Authors

Henry N. Wagner · Johns Hopkins University

H. Donald Burns · Johns Hopkins University

Robert F. Dannals · Johns Hopkins University

Dean F. Wong · Johns Hopkins University

Bengt Långström · Uppsala University

Timothy Duelfer · Johns Hopkins University

J. James Frost ·

Abstract

Neurotransmitter receptors may be involved in a number of neuropsychiatric disease states. The ligand 3-N-[11C]methylspiperone, which preferentially binds to dopamine receptors in vivo, was used to image the receptors by positron emission tomography scanning in baboons and in humans. This technique holds promise for noninvasive clinical studies of dopamine receptors in humans.

Topics & Keywords

Medical Imaging Techniques and Applications Advanced MRI Techniques and Applications Atomic and Subatomic Physics Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Science

Volume 221, Issue 4617, pp. 1264-1266

DOI: 10.1126/science.6604315

Field-Weighted Citation Impact: 29.41