Molecular Predictors of Survival after Adjuvant Chemotherapy for Colon Cancer

2001894 citationsJournal Articlebronze Open Access

Authors

Toshiaki Watanabe · Johns Hopkins University

Tsung‐Teh Wu

Paul J. Catalano · Dana-Farber Cancer Institute

Takashi Ueki

Robert Satriano

Daniel G. Haller · University of Pennsylvania

Al B. Benson · Robert H. Lurie Comprehensive Cancer Center of Northwestern University

Stanley R. Hamilton · The University of Texas MD Anderson Cancer Center

Abstract

Retention of 18q alleles in microsatellite-stable cancers and mutation of the gene for the type II receptor for TGF-beta1 in cancers with high levels of microsatellite instability point to a favorable outcome after adjuvant chemotherapy with fluorouracil-based regimens for stage III colon cancer.

Topics & Keywords

Genetic factors in colorectal cancer Colorectal Cancer Treatments and Studies Cholangiocarcinoma and Gallbladder Cancer Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 344, Issue 16, pp. 1196-1206

DOI: 10.1056/nejm200104193441603

Field-Weighted Citation Impact: 36.50