MicroRNA history: Discovery, recent applications, and next frontiers

2011433 citationsReviewgreen Open Access

Authors

Maria Inês Almeida · The University of Texas MD Anderson Cancer Center

George A. Călin · The University of Texas MD Anderson Cancer Center

Abstract

Since 1993, when the first small non-coding RNA was identified, our knowledge about microRNAs has grown exponentially. In this review, we focus on the main progress in this field and discuss the most important findings under a historical perspective. In addition, we examine microRNAs as markers of disease diagnosis and prognosis, and as new therapeutic targets.

Topics & Keywords

MicroRNA in disease regulation Cancer-related molecular mechanisms research Circular RNAs in diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Mutation research. Fundamental and molecular mechanisms of mutagenesis

Volume 717, Issue 1-2, pp. 1-8

DOI: 10.1016/j.mrfmmm.2011.03.009

Field-Weighted Citation Impact: 7.98