The differential effects of statins on the metastatic behaviour of prostate cancer

201295 citationsJournal Articlehybrid Open Access

Authors

M.D. Brown · Cancer Research UK Manchester Institute

Claire A. Hart · The Christie NHS Foundation Trust

Thomas Tawadros · Manchester Academic Health Science Centre

Vijay Ramani · The Christie NHS Foundation Trust

Vijay Sangar · Manchester University NHS Foundation Trust

Mai Chan Lau · The Christie NHS Foundation Trust

Noel W. Clarke

Abstract

Lipophilic statins reduce the migration and colony formation of PC-3 cells in human BMS by inhibiting GGPP production, reducing the formation and the spread of metastatic prostate colonies.

Topics & Keywords

Cancer, Lipids, and Metabolism Lipoproteins and Cardiovascular Health Ferroptosis and cancer prognosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Cancer

Volume 106, Issue 10, pp. 1689-1696

DOI: 10.1038/bjc.2012.138

Field-Weighted Citation Impact: 3.75