Age-Related Changes in Thyroid Function: A Longitudinal Study of a Community-Based Cohort

2012322 citationsJournal Articlebronze Open Access

Authors

Alexandra Bremner · University of Western Australia

Peter Feddema · Pathwest Laboratory Medicine

Peter J. Leedman · Royal Perth Hospital

Suzanne J. Brown · Curtin University

John Beilby · Pathwest Laboratory Medicine

Ee Mun Lim · Pathwest Laboratory Medicine

Scott G. Wilson ·

Abstract

Aging is associated with increased serum TSH concentrations, with no change in free T(4) concentrations. The largest TSH increase is in people with the lowest TSH at baseline. This suggests that the TSH increase arises from age-related alteration in the TSH set point or reduced TSH bioactivity rather than occult thyroid disease.

Topics & Keywords

Thyroid Disorders and Treatments Thyroid Cancer Diagnosis and Treatment Vitamin D Research Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 97, Issue 5, pp. 1554-1562

DOI: 10.1210/jc.2011-3020

Field-Weighted Citation Impact: 12.94

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