Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects

20061,303 citationsJournal Articlebronze Open Access

Authors

Timothy E. Graham · Harvard University

Qin Yang

Matthias Blüher

Ann Hammarstedt

Theodore P. Ciaraldi · University of California, San Diego

Robert R. Henry · University of California, San Diego

Abstract

RBP4 is an adipocyte-secreted molecule that is elevated in the serum before the development of frank diabetes and appears to identify insulin resistance and associated cardiovascular risk factors in subjects with varied clinical presentations. These findings provide a rationale for antidiabetic therapies aimed at lowering serum RBP4 levels.

Topics & Keywords

Retinoids in leukemia and cellular processes Adipokines, Inflammation, and Metabolic Diseases Antioxidant Activity and Oxidative Stress

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 354, Issue 24, pp. 2552-2563

DOI: 10.1056/nejmoa054862

Field-Weighted Citation Impact: 47.38