Opiate Receptor: Demonstration in Nervous Tissue

19732,370 citationsJournal Article

Authors

Candace B. Pert · Johns Hopkins University

Solomon H. Snyder · Johns Hopkins University

Abstract

Tritiated naloxone, a powerful opiate antagonist, specifically binds to an opiate receptor of mammalian brain and guinea pig intestine. Competition for the opiate receptor by various opiates and their antagonists closely parallels their pharmacological potency. The opiate receptor is confined to nervous tissue.

Topics & Keywords

Neuropeptides and Animal Physiology Pharmacological Receptor Mechanisms and Effects Receptor Mechanisms and Signaling

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Science

Volume 179, Issue 4077, pp. 1011-1014

DOI: 10.1126/science.179.4077.1011

Field-Weighted Citation Impact: 28.02