Mecamylamine Suppresses Basal and Nicotine-Stimulated Choroidal Neovascularization

200861 citationsJournal Articlebronze Open Access

Authors

Katsuji Kiuchi · Johns Hopkins University

Masato Matsuoka · Johns Hopkins University

Jenny Wu · Stanford University

Raquel Lima e Silva · Johns Hopkins University

Muralitharan Kengatharan · CoMentis (United States)

Verghese Mary · CoMentis (United States)

Shinji Ueno ·

Abstract

These data suggest that endogenous activation of nAChR promotes CNV and that activation of nAChR by nicotine may contribute to the increased incidence of CNV seen in smokers with age-related macular degeneration (AMD). Topically administered mecamylamine could provide an appealing new treatment approach for CNV.

Topics & Keywords

Retinal Diseases and Treatments Retinal Development and Disorders Nicotinic Acetylcholine Receptors Study

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Investigative Ophthalmology & Visual Science

Volume 49, Issue 4, pp. 1705-1705

DOI: 10.1167/iovs.07-0089

Field-Weighted Citation Impact: 6.84