Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells

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Authors

Stavros Selemidis · The University of Melbourne

G. J. Dusting · The University of Melbourne

Hitesh Peshavariya · The University of Melbourne

Barbara K. Kemp‐Harper · Monash University

Abstract

NO causes sustained suppression of NADPH oxidase-dependent superoxide production in human endothelial cells by S-nitrosylation of p47phox. These findings highlight a novel approach by which vascular oxidative stress might be suppressed by NO donors.

Topics & Keywords

Nitric Oxide and Endothelin Effects Neutrophil, Myeloperoxidase and Oxidative Mechanisms Neuroinflammation and Neurodegeneration Mechanisms

Publication Details

Published in: Cardiovascular Research

Volume 75, Issue 2, pp. 349-358

DOI: 10.1016/j.cardiores.2007.03.030

Field-Weighted Citation Impact: 8.22

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Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells

Authors

Abstract

Topics & Keywords

Publication Details