ADME pharmacogenetics: investigation of the pharmacokinetics of the antiretroviral agent lopinavir coformulated with ritonavir

2010112 citationsJournal Article

Authors

Rubin Lubomirov

Julia di Iulio

Aurélie Fayet · University of Lausanne

Sara Colombo

Raquel Martínez

Catia Marzolini · University Hospital of Basel

Hansjakob Furrer · University of Bern

Pietro Vernazza · University of St. Gallen

Alexandra Calmy

Abstract

The two-stage strategy successfully identified genetic variants affecting LPV/r pharmacokinetics. Such a general approach of ADME pharmacogenetics should be generalized to other drugs.

Topics & Keywords

HIV/AIDS drug development and treatment HIV Research and Treatment Pharmacogenetics and Drug Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Pharmacogenetics and Genomics

Volume 20, Issue 4, pp. 217-230

DOI: 10.1097/fpc.0b013e328336eee4

Field-Weighted Citation Impact: 6.43