Asymmetric syntheses of (+)-diltiazem hydrochloride

199071 citationsJournal Article

Authors

Keith G. Watson

Yik M. Fung

Matthew Gredley

G. J. BIRD

W. R. JACKSON

Helen Gountzos · Australian Regenerative Medicine Institute

Barry Matthews · Australian Regenerative Medicine Institute

Abstract

Efficient enantioselective syntheses of the important cardiac drug (+)-cis-(2S,3S)-diltiazem from (E)-methyl 4-methoxyphenylpropenoate via either the (2R,3S)- or (2S,3R)-enantiomers of threo-methyl 3-(4-methoxyphenyl)-2,3-dihydroxypropanoate are described.

Topics & Keywords

Chemical synthesis and alkaloids Asymmetric Synthesis and Catalysis Coordination Chemistry and Organometallics

Publication Details

Published in: Journal of the Chemical Society Chemical Communications

DOI: 10.1039/c39900001018

Field-Weighted Citation Impact: 3.28

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Asymmetric syntheses of (+)-diltiazem hydrochloride

Authors

Abstract

Topics & Keywords

Publication Details