Topotecan Chemotherapy in Patients with Breast Cancer and Brain Metastases: Results of a Pilot Study

2001100 citationsJournal Article

Authors

C. Oberhoff · Essen University Hospital

D. G. Kieback

Rachel Würstlein · Leopoldina Krankenhaus Schweinfurt

Holger Deertz · Evangelisches Krankenhaus Oberhausen

Jalid Sehouli · Charité - Universitätsmedizin Berlin

C. van Soest · Marien Hospital Wesel

J. Hilfrich · Klinik Bethesda

Abstract

Our results demonstrate that primary chemotherapy with topotecan is an effective and well-tolerated treatment for patients with breast cancer and CNS metastases. Based on this pilot study, future clinical protocols should be developed including multimodal treatment strategies (i.e. radiotherapy).

Topics & Keywords

Cancer therapeutics and mechanisms Brain Metastases and Treatment Lung Cancer Research Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Oncology Research and Treatment

Volume 24, Issue 3, pp. 256-260

DOI: 10.1159/000055088

Field-Weighted Citation Impact: 1.02