Myocardial Infarction and Apoptosis After Myocardial Ischemia and Reperfusion

1998393 citationsJournal Articlebronze Open Access

Authors

Antti Väkevä · Alexion Pharma (Switzerland)

Azin Agah · Alexion Pharma (Switzerland)

Scott A. Rollins · Alexion Pharmaceuticals (France)

Louis A. Matis · Alexion Pharma (Switzerland)

Lan Li · Alexion Pharma (Switzerland)

Gregory L. Stahl · Alexion Pharmaceuticals (France)

Abstract

Anti-C5 therapy in the setting of MI/R significantly inhibits cell apoptosis, necrosis, and PMN infiltration in the rat despite C3 deposition. We conclude that the terminal complement components C5a and C5b-9 are key mediators of tissue injury in MI/R.

Topics & Keywords

Cardiac Ischemia and Reperfusion Cardiac Imaging and Diagnostics Cardiac electrophysiology and arrhythmias

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 97, Issue 22, pp. 2259-2267

DOI: 10.1161/01.cir.97.22.2259

Field-Weighted Citation Impact: 13.67