Estrogen plus Progestin and the Risk of Coronary Heart Disease

20032,058 citationsJournal Articlebronze Open Access

Authors

JoAnn E. Manson · Brigham and Women's Hospital

Judith Hsia · George Washington University

Karen Johnson · University of Tennessee Health Science Center

Jacques E. Rossouw

Annlouise R. Assaf

Norman L. Lasser · Rutgers, The State University of New Jersey

Maurizio Trevisan

Henry R. Black · Rush University Medical Center

Abstract

Estrogen plus progestin does not confer cardiac protection and may increase the risk of CHD among generally healthy postmenopausal women, especially during the first year after the initiation of hormone use. This treatment should not be prescribed for the prevention of cardiovascular disease.

Topics & Keywords

Menopause: Health Impacts and Treatments Estrogen and related hormone effects Sex and Gender in Healthcare

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 349, Issue 6, pp. 523-534

DOI: 10.1056/nejmoa030808

Field-Weighted Citation Impact: 109.15