Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure

2006110 citationsJournal Article

Authors

Christian R. Gómez · Loyola University Medical Center

Stefanie A. Hirano · CRG Services (United States)

Brent T. Cutro · CRG Services (United States)

Shirin Birjandi · CRG Services (United States)

Horea Baila · CRG Services (United States)

Vanessa Nomellini · CRG Services (United States)

Elizabeth J. Kovacs

Abstract

The hyperreactive systemic inflammatory response seen in aged individuals after lipopolysaccharide administration is accompanied by an exacerbated pulmonary inflammatory response, which may contribute to the higher mortality seen in the aged given an inflammatory insult.

Topics & Keywords

Immune Response and Inflammation Respiratory Support and Mechanisms Inflammation biomarkers and pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Critical Care Medicine

Volume 35, Issue 1, pp. 246-251

DOI: 10.1097/01.ccm.0000251639.05135.e0

Field-Weighted Citation Impact: 1.68