Activation of MMP‐2 and MMP‐9 in patients with oral squamous cell carcinoma

2005110 citationsJournal Article

Authors

Beena P. Patel · Gujarat Cancer & Research Institute

Pankaj Shah · Gujarat Cancer & Research Institute

Upendra M. Rawal · Gujarat University

Amisha Desai · Gujarat Cancer Society

Shakuntala V. Shah · Gujarat Cancer & Research Institute

Rakesh Rawal · Gujarat Cancer & Research Institute

Prabhudas S. Patel

Abstract

The study concluded that activation of MMP-2 and MMP-9 was significantly higher in malignant tissues as compared to adjacent normal tissues. Further, activation ratio of MMP-2 was significantly elevated in patients with lymph node metastasis as compared to patients without lymph node metastasis, which could predict risk of lymph node metastasis development in node negative patients.

Topics & Keywords

Protease and Inhibitor Mechanisms Peptidase Inhibition and Analysis Oral microbiology and periodontitis research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Surgical Oncology

Volume 90, Issue 2, pp. 81-88

DOI: 10.1002/jso.20240

Field-Weighted Citation Impact: 2.05