DNA Damage, Aging, and Cancer

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Authors

Abstract

This review gives an account of how the cell repairs DNA damage and presents evidence that DNA damage contributes to aging and cancer, with the outcome dependent on the type and number of lesions in DNA. Examples of accelerated aging syndromes associated with defects in DNA repair mechanisms are contrasted with cancers.

Topics & Keywords

DNA Repair Mechanisms Carcinogens and Genotoxicity Assessment Telomeres, Telomerase, and Senescence

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 361, Issue 15, pp. 1475-1485

DOI: 10.1056/nejmra0804615

Field-Weighted Citation Impact: 37.34