High-Density Lipoproteins Inhibit Vascular Endothelial Inflammation by Increasing 3β-Hydroxysteroid-Δ24 Reductase Expression and Inducing Heme Oxygenase-1

201281 citationsJournal Articlebronze Open Access

Authors

Ben J. Wu · University of Sydney

Kang Chen · University of Sydney

Sudichhya Shrestha · University of Sydney

Kwok Leung Ong · University of Sydney

Philip J. Barter · University of Sydney

Kerry‐Anne Rye · University of Sydney

Abstract

Lipid-free apoA-I and (A-I)rHDL inhibit inflammation by increasing DHCR24 expression, which, in turn, activates phosphatidylinositol 3-kinase/Akt and induces HO-1.

Topics & Keywords

Heme Oxygenase-1 and Carbon Monoxide Eicosanoids and Hypertension Pharmacology Alcohol Consumption and Health Effects

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 112, Issue 2, pp. 278-288

DOI: 10.1161/circresaha.111.300104

Field-Weighted Citation Impact: 3.36