Simple Method for the Esterification of Carboxylic Acids

19782,015 citationsJournal Article

Authors

Abstract

Addition of 4‐dimethylaminopyridine (DMAP) accelerates the dicyclohexylcarbo‐diimide (DCC)‐activated esterification of carboxylic acids to such an extent that side reactions are eliminated and even sensitive acids such 2,5‐cyclohexadiene‐1‐carboxylic acid readily form the tert ‐butyl ester. DMAP has so far been used mainly as acylation catalyst. equation image

Topics & Keywords

Chemical Synthesis and Reactions Inorganic and Organometallic Chemistry Synthetic Organic Chemistry Methods

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Angewandte Chemie International Edition in English

Volume 17, Issue 7, pp. 522-524

DOI: 10.1002/anie.197805221

Field-Weighted Citation Impact: 14.56