Imaging amyloid deposition in Lewy body diseases

2008446 citationsJournal Articlegreen Open Access

Authors

Stephen N. Gomperts · Jacobson Holman (United States)

Dorene M. Rentz · Jacobson Holman (United States)

Erin K. Moran · Jacobson Holman (United States)

J. Alex Becker · Jacobson Holman (United States)

Joseph J. Locascio · Jacobson Holman (United States)

William E. Klunk · Jacobson Holman (United States)

Chester A. Mathis

Abstract

Global cortical amyloid burden is high in dementia with Lewy bodies (DLB) but low in Parkinson disease dementia. These data suggest that beta-amyloid may contribute selectively to the cognitive impairment of DLB and may contribute to the timing of dementia relative to the motor signs of parkinsonism.

Topics & Keywords

Dementia and Cognitive Impairment Research Parkinson's Disease Mechanisms and Treatments Alzheimer's disease research and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 71, Issue 12, pp. 903-910

DOI: 10.1212/01.wnl.0000326146.60732.d6

Field-Weighted Citation Impact: 22.27