Enantioselective Direct Amination of α-Cyanoacetates Catalyzed by Bifunctional Chiral Ru and Ir Amido Complexes

200893 citationsJournal Article

Authors

Yasuharu Hasegawa · Kanto Chemical (Japan)

Masahito Watanabe · Tokyo Institute of Technology

Ilya D. Gridnev · Tokyo Institute of Technology

Abstract

The bifunctional chiral amido Ir complex catalyzed asymmetric electrophilic direct amination of α-substituted α-cyanoacetates using azodicarboxylates proceeds rapidly to provide the corresponding hydrazine adducts in high yields and with excellent ee values.

Topics & Keywords

Asymmetric Hydrogenation and Catalysis Chemical Synthesis and Analysis Synthesis and Catalytic Reactions

Publication Details

Published in: Journal of the American Chemical Society

Volume 130, Issue 7, pp. 2158-2159

DOI: 10.1021/ja710273s

Field-Weighted Citation Impact: 6.30

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Enantioselective Direct Amination of α-Cyanoacetates Catalyzed by Bifunctional Chiral Ru and Ir Amido Complexes

Authors

Abstract

Topics & Keywords

Publication Details