The Dose-Response Relationship of Tranexamic Acid

1995309 citationsJournal Articlebronze Open Access

Authors

Jan C. Horrow · College of Physicians of Philadelphia

Michael D. Strong · Essex Cardiothoracic Centre

Karl Grunewald · Essex Cardiothoracic Centre

Abstract

Prophylactic tranexamic acid, 10 mg.kg-1 followed by 1 mg.kg-1.h-1, decreases bleeding after extracorporeal circulation. Larger doses do not provide additional hemostatic benefit.

Topics & Keywords

Blood transfusion and management Trauma, Hemostasis, Coagulopathy, Resuscitation Blood groups and transfusion

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Anesthesiology

Volume 82, Issue 2, pp. 383-392

DOI: 10.1097/00000542-199502000-00009

Field-Weighted Citation Impact: 5.44