Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD)

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Authors

Masato Yoneda · Yokohama City University

Kikuko Hotta · RIKEN Center for Integrative Medical Sciences

Yuichi Nozaki · Yokohama City University

Hiroki Endo · Yokohama City University

Takashi Uchiyama · Yokohama City University

Hironori Mawatari · Yokohama City University

Hiroshi Iida ·

Abstract

This is the first study to demonstrate a significant association between genetic variations in PPARGC1A and NAFLD. This finding suggested that PPARGC1A polymorphism and lower expression of PPARGC1A mRNA in the liver are an important genetic contribution to etiology of NAFLD.

Topics & Keywords

Liver Disease Diagnosis and Treatment Peroxisome Proliferator-Activated Receptors Lipid metabolism and disorders

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: BMC Gastroenterology

Volume 8, Issue 1, pp. 27-27

DOI: 10.1186/1471-230x-8-27

Field-Weighted Citation Impact: 3.41