Characterization of LEDGF/p75 Genetic Variants and Association with HIV-1 Disease Progression

201211 citationsJournal Articlegold Open Access

Authors

Peter Messiaen · Ghent University Hospital

Ward De Spiegelaere · Ghent University Hospital

José Alcamı́ · Instituto de Salud Carlos III

Karen Vervisch · Ghent University Hospital

Petra Van Acker · Ghent University Hospital

Bruno Verhasselt · Ghent University Hospital

Pieter Meuwissen

Abstract

LEDGF/p75 is a highly conserved protein. Two non-coding polymorphisms were identified indicating a correlation with disease outcome, but further research is needed to clarify phenotypic impact. The conserved coding region and the observed variation in LEDGF/p75 expression are important characteristics for clinical use of LEDGINs.

Topics & Keywords

HIV Research and Treatment HIV/AIDS drug development and treatment Biochemical and Molecular Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 7, Issue 11, pp. e50204-e50204

DOI: 10.1371/journal.pone.0050204

Field-Weighted Citation Impact: 1.07