Berberine derivatives as antileishmanial drugs

1990126 citationsJournal Article

Authors

Jonathan L. Vennerstrom · Walter Reed Army Institute of Research

James K. Lovelace · Walter Reed Army Institute of Research

Virginia B. Waits · Walter Reed Army Institute of Research

William L. Hanson · Walter Reed Army Institute of Research

Daniel L. Klayman · Walter Reed Army Institute of Research

Abstract

Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not as potent as meglumine antimonate (Glucantime), a standard drug for the treatment of leishmaniasis. Only berberine and 8-cyanodihydroberberine showed significant activity (greater than 50% suppression of lesion size) against L. braziliensis panamensis.

Topics & Keywords

Research on Leishmaniasis Studies Trypanosoma species research and implications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Antimicrobial Agents and Chemotherapy

Volume 34, Issue 5, pp. 918-921

DOI: 10.1128/aac.34.5.918

Field-Weighted Citation Impact: 1.00