Glutathione Peroxidase 1 Activity and Cardiovascular Events in Patients with Coronary Artery Disease

2003590 citationsJournal Articlebronze Open Access

Authors

Stefan Blankenberg · Inserm

Hans J. Rupprecht · Johannes Gutenberg University Mainz

Christoph Bickel · Bundeswehrzentralkrankenhaus Koblenz

Michael Torzewski · University Medical Center of the Johannes Gutenberg University Mainz

Gerd Häfner · Johannes Gutenberg University Mainz

Laurence Tiret · Inserm

Marek Smieja

Abstract

In patients with coronary artery disease, a low level of activity of red-cell glutathione peroxidase 1 is independently associated with an increased risk of cardiovascular events. Glutathione peroxidase 1 activity may have prognostic value in addition to that of traditional risk factors. Furthermore, increasing glutathione peroxidase 1 activity might lower the risk of cardiovascular events.

Topics & Keywords

Antioxidant Activity and Oxidative Stress Cardiovascular, Neuropeptides, and Oxidative Stress Research Paraoxonase enzyme and polymorphisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 349, Issue 17, pp. 1605-1613

DOI: 10.1056/nejmoa030535

Field-Weighted Citation Impact: 11.88