Influenza A H5N1 Clade 2.3.4 Virus with a Different Antiviral Susceptibility Profile Replaced Clade 1 Virus in Humans in Northern Vietnam

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Authors

Mai thi Quynh Le · National Institute Of Hygiene And Epidemiology

Heiman Wertheim · Oxford University Clinical Research Unit

Hien Duc Nguyen · Hospital for Tropical Diseases

Walter Taylor · Oxford University Clinical Research Unit

Phuong Vu Mai Hoang · National Institute Of Hygiene And Epidemiology

Cuong Duc Vuong · National Institute Of Hygiene And Epidemiology

Hang Le Khanh Nguyen

Abstract

In 2007, H5N1 clade 2.3.4 viruses replaced clade 1 viruses in northern Vietnam and were susceptible to amantadine but showed reduced susceptibility to oseltamivir. Combination antiviral therapy with oseltamivir and amantadine for human cases in Vietnam is recommended.

Topics & Keywords

Influenza Virus Research Studies Respiratory viral infections research Animal Disease Management and Epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 3, Issue 10, pp. e3339-e3339

DOI: 10.1371/journal.pone.0003339

Field-Weighted Citation Impact: 7.82