Ischemia-Induced Coronary Collateral Growth Is Dependent on Vascular Endothelial Growth Factor and Nitric Oxide

2000233 citationsJournal Article

Authors

Toshiro Matsunaga · Medical College of Wisconsin

David C. Warltier · Medical College of Wisconsin

Dorothee W. Weihrauch · Medical College of Wisconsin

Melinda Moniz · Medical College of Wisconsin

John P. Tessmer · Medical College of Wisconsin

William M. Chilian · Medical College of Wisconsin

Abstract

NO is an important regulator of coronary collateral growth, and the expression of VEGF is induced by ischemia. Furthermore, the induction of coronary collateralization by VEGF appears to require the production of NO.

Topics & Keywords

Nitric Oxide and Endothelin Effects Eicosanoids and Hypertension Pharmacology Angiogenesis and VEGF in Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 102, Issue 25, pp. 3098-3103

DOI: 10.1161/01.cir.102.25.3098

Field-Weighted Citation Impact: 6.90