Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia

200664 citationsJournal Article

Authors

Samart Pakakasama · Ramathibodi Hospital

Tanasan Sirirat · Huachiew Chalermprakiet University

Saowanee Kanchanachumpol · Mahidol University

Umaporn Udomsubpayakul · Mahidol University

Surakameth Mahasirimongkol · Mahidol University

Pimpun Kitpoka · Mahidol University

Amnuay Thithapandha

Abstract

The XRCC1 194Trp allele and haplotype B showed a protective effect against development of childhood ALL. In contrast, individuals with the XRCC1 399Gln allele and haplotype C were associated with increased risk for this disease.

Topics & Keywords

DNA Repair Mechanisms Acute Lymphoblastic Leukemia research Genetic factors in colorectal cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Pediatric Blood & Cancer

Volume 48, Issue 1, pp. 16-20

DOI: 10.1002/pbc.20742

Field-Weighted Citation Impact: 1.85