MicroRNA Expression Profiling of Thyroid Tumors: Biological Significance and Diagnostic Utility

2008582 citationsJournal Articlebronze Open Access

Authors

Marina N. Nikiforova · University of Pittsburgh

George C. Tseng · University of Pittsburgh Medical Center

David L. Steward · University of Cincinnati Medical Center

Donna Diorio · Cincinnati Children's Hospital Medical Center

Yuri E. Nikiforov · University of Pittsburgh

Abstract

In this study, we demonstrate that various histopathological types of thyroid tumors have distinct miRNA profiles, which further differ within the same tumor type, reflecting specific oncogenic mutations. A limited set of miRNAs can be used diagnostically with high accuracy to detect thyroid cancer in the surgical and preoperative FNA samples.

Topics & Keywords

MicroRNA in disease regulation Cancer-related molecular mechanisms research Thyroid Cancer Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 93, Issue 5, pp. 1600-1608

DOI: 10.1210/jc.2007-2696

Field-Weighted Citation Impact: 15.94