THE RADIOIMMUNOASSAY OF CIRCULATING CARCINOEMBRYONIC ANTIGEN OF THE HUMAN DIGESTIVE SYSTEM

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Authors

David M. Thomson · Montreal General Hospital

Samuel O. Freedman · Montreal General Hospital

Abstract

A radioimmunoassay has been developed for determining the serum levels of carcinoembryonic antigen of the human digestive system in patients with cancer of the colon and rectum. The assay is simple to perform and has a high degree of reproducibility and specificity. The test detects a concentration of 2.5 ng of carcinoembryonic antigen per ml of serum and this has provided the first demonstration of a circulating tumor-specific antigen in the sera of cancer patients.

Topics & Keywords

Radiopharmaceutical Chemistry and Applications Monoclonal and Polyclonal Antibodies Research Glycosylation and Glycoproteins Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Proceedings of the National Academy of Sciences

Volume 64, Issue 1, pp. 161-167

DOI: 10.1073/pnas.64.1.161

Field-Weighted Citation Impact: 62.27